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Check Closely (one)phenobarbital will minimize the extent or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to some reduce in fentanyl plasma concentrations, insufficient efficacy or, quite possibly, advancem

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